Tuesday, January 28, 2020

Legal and Practical Impact of Insolvency

Legal and Practical Impact of Insolvency Introduction The dissertation is going to consider the topical area of insolvency and the impact that it has on contracts that are in place with the insolvent company. A company may enter insolvency proceedings either voluntarily or be forced into the position by creditors and/or members. Similar processes exist for partnerships[1]. However, when a company enters into a position of insolvency, this creates a potentially difficult position in relation to the contracts that have been entered into on behalf of the company, prior to the company entering into insolvency and ultimately being dissolved. This research paper will look at the effects that insolvency has on these contracts, both in terms of commercial contracts and employment contracts. It will consider not only the legal impact but also the reality of how these situations are dealt with regarding the practicalities[2]. Hypothesis It is suggested that when a company enters into insolvency proceedings, whether on a voluntary basis or on a compulsory basis, the legal structure of what should happen to the relevant contracts is not, in fact, in line with what actually occurs. In reality, those involved in company insolvency will ensure that the contracts simply do not collapse but rather that economic value which exists in the contracts is maintained as much as is possible in the circumstances[3]. Objectives The main objectives of this research are to consider the legal and real impact of insolvency proceedings on contracts that are in place with the newly insolvent company. As a company can enter into contracts as its own distinct legal entity, this can result in a position where one party of the contract ceases to exist[4]. The aim of the research is to consider what should happen from a purely legal point of view in relation to the contracts that a company has entered into when it becomes insolvent and how this relates to the reality of what actually occurs. Due to the nature of commercial and employment contracts and the different legal principles that apply to these types of contracts and the potentially different implications that may arise from the treatments of these contracts, they should be analysed independently. It is suggested that the strict legal position is rarely followed due to the complex nature of the situation and this research aims to ascertain whether or not this statement is accurate[5]. Methodology Several different methods will be followed during this research. Initially, research and analysis will be conducted into what the strict legal position should be. This will involve looking at the relevant legislation and the way in which this should be interpreted strictly in relation to both types of contracts[6]. After the strict legal position has been ascertained, the case law relating to how this legislation has been applied, practically, in the courts will be established. A range of contracts (both commercial and employment) will be considered and looked at in order to ascertain what the agreed clauses state should happen during insolvency and how these issues are dealt with during court cases. At this point, it would also be helpful to consider what happens in other jurisdictions, both across the European Union and in one other developed country, in particular, such as the USA. Research will also be conducted as to what is used as the main alternative to insolvency, i.e. distressed business sales or carving up of assets. Perceptions are important in this field. Therefore, part of the research will be conducted with first hand interviews and questionnaires of business people (ideally company directors) on how they believe the contracts would work in the event of insolvency. This perception will then be compared with what is written in the contracts to see if the real perceptions meet with the legal drafting[7]. The research will focus on gaining a strict legal view as well as an understanding of what happens, in reality, in relation to the basic principles of contract, i.e. is there any difference between executed and non-executed contracts? Are there any differences, in reality, to the way contracts that are now frustrated are dealt with, in comparison to ones that could be performed adequately by another party? Limitation Commercial and employment contracts are often sensitive in their nature and not readily available for analysis. More specifically, companies that are entering into an insolvency scenario will be extremely reluctant to give information readily that relates to their commercial contracts. Many deals that are done with a company which is entering insolvency will be negotiated rapidly and with commercial secrecy, making the research particularly difficult to undertake. Insolvency is often something that businesses are simply unprepared to consider or discuss, as discussion of such issues can be seen as a sign of weakness. On this basis, it may prove difficult to speak to a sufficient number of directors about insolvency provisions[8]. Resources Resources used in this research will be relatively variable. Firstly, and arguably the most important resource, will be the legislation that underlies the area of insolvency law[9]. This is the fundamental part of the legal area of insolvency and will be the background for the remaining part of the research. Case law and analysis of legislation will then form the secondary part of the research when looking at the way in which the legislation actually operates on a practical level. Once the legal position has been established, direct contact will have to be made with individual companies. These resources will include questionnaires, direct analyses of the relevant contracts and perceptions of the contractual terms that are in place, in the event of insolvency. Commercial and employment contracts will be looked at separately due to their considerable differences in content, legal position and scope[10]. Timetable This research is expected to span a period of at least 8 months. The initial part of the research considering the legal context and provisions of the relevant legislation will create the foundation of the research and will be undertaken in the first 2 months of the research timetable. Towards the end of the first 2-month period, the case law and journals analysing the relevant legislation will provide the supplemental part of this initial research. After a full understanding of the legislation has been obtained, the research will move on to considering the practical reality of what happens in insolvency situations. Questionnaires and interviews will be conducted over a period of 2 months, with the remaining 3 months of the research being used to consolidate and conclude, based on the information gathered. Suggested Chapters Suggested initial chapters will include methodology and research background. In the main body of the research, the findings will be broken down to contain legislative provisions (both employment and commercial), case law and legal analysis relating to the legislation, directors’ perceptions, contractual provisions and overall conclusions drawing all information together[11]. It is anticipated that the conclusion section will draw together all of the above information and findings to establish whether or not the legal provisions relating to insolvency are followed, in practice, when a company enters into a position of insolvency. Bibliography Brousseau, Eric, Glachant, Jean-Michel, The Economics of Contracts: Theories and Applications, Cambridge University Press, 2002 Dickerson, A. Mechele, Insolvency Principles and the Odious Debt Doctrine: The Missing Link in the Debate, Law and Contemporary Problems, 70, 2007 Fletcher, Ian F., Insolvency in Private International Law: National and International Approaches, Oxford University Press, 1999 Goode, Royston Miles, Principles of Corporate Insolvency Law, Sweet Maxwell, 2005 Marsh, S.B., Soulsby, J., Business Law, Nelson Thornes, 2002 McKendrick, Ewan, Commercial Aspects of Trusts and Fiduciary Obligations, Oxford University Press 1992 Schwartz, Alan, A Contract Theory Approach to Business Bankruptcy, Yale Law Journal, 107, 1998 Schwartz, Alan, Bankruptcy Contracting Reviewed, Yale Law Journal, 109, 1999 Thorpe, Chris P., Bailey, John C.L., Commercial Contracts: A Practical Guide to Deals, Contracts, Agreements and Promises, Institute of Directors, Kogan Page Publishers, 1999 Unt, Lore, International Relations and International Insolvency Cooperation: Liberalism, Institutionalism, and Transnational Legal Dialogue, Law and Policy in International Business, 28, 1997 Yemin, Edward, Bronstein, Arturo S., The Protection of Workers Claims in the Event of the Employers Insolvency, International Labour Office, International Labour Organization, 1991 Footnotes [1] Fletcher, Ian F., Insolvency in Private International Law: National and International Approaches, Oxford University Press, 1999 [2] Brousseau, Eric, Glachant, Jean-Michel, The Economics of Contracts: Theories and Applications, Cambridge University Press, 2002 [3] Yemin, Edward, Bronstein, Arturo S., The Protection of Workers Claims in the Event of the Employers Insolvency, International Labour Office, International Labour Organization, 1991 [4] Marsh, S.B., Soulsby, J., Business Law, Nelson Thornes, 2002 [5] Schwartz, Alan, A Contract Theory Approach to Business Bankruptcy, Yale Law Journal, 107, 1998 [6] Dickerson, A. Mechele, Insolvency Principles and the Odious Debt Doctrine: The Missing Link in the Debate, Law and Contemporary Problems, 70, 2007 [7] Goode, Royston Miles, Principles of Corporate Insolvency Law, Sweet Maxwell, 2005 [8] Schwartz, Alan, Bankruptcy Contracting Reviewed, Yale Law Journal, 109, 1999 [9] Thorpe, Chris P., Bailey, John C. L., Commercial Contracts: A Practical Guide to Deals, Contracts, Agreements and Promises, Institute of Directors, Kogan Page Publishers, 1999 [10] Unt, Lore, International Relations and International Insolvency Cooperation: Liberalism, Institutionalism, and Transnational Legal Dialogue, Law and Policy in International Business, 28, 1997 [11] McKendrick, Ewan; Commercial Aspects of Trusts and Fiduciary Obligations, Oxford University Press, 1992

Monday, January 20, 2020

The Struggles Facing LD Students Essay -- Learning Disabilities Educat

The Struggles Facing LD Students Students with learning disabilities are a part of the educational system and they always will be. These students have a single goal in mind, but their disability and social barriers keep them from it. On the other hand, educators have pledged to teach all students, but some fail to teach LD students. This represents an ethical, moral, and legal breakdown of their responsibilities. Educators need to be properly trained and aware of how to meet the needs of these students. The lack of such leads to failure. Students fail because they are afflicted by a disability that forces them to learn in unconventional ways. Teachers fail because they do not embrace the challenge brought about by the diversity of the situation. Students, all over the world, enter into a classroom environment all with a common purpose. The purpose is to learn and excel in all subject areas. This purpose is the same whether the student is in kindergarten or at the university level. The same is true for male and female students, and it is also the case for students who have a learning disability. For these students, the goal is the same, but they can not effectively learn without the help of educators. Learning disabilities alter how these students learn; therefore, the outcome changes. It becomes one of failure and frustration. The student with the disability fails, and educators become frustrated and discouraged. Learning Disabilities (LD) are hidden (obscure) disabilities that affect many people. These people usually have average or above average intelligence, but they are not able to achieve their full potential. The Learning Disability Institute estimates that 5 to 20% of the school-age population has a Specific Le... ... unified purpose. The purpose for the student is to learn while the teacher's purpose is to help that student learn. Learning Disabilities stand in the way of this unified purpose of learning/teaching. Students with a learning disability encounter untrained, unwilling educators who are not prepared to teach them. Students fail because educators fail to live up to their moral and legal obligation to make accommodations to meet their needs. This outcome makes educators also a failure because their goal (to teach all students) is not met. Works Cited "About Learning Disabilities." http://www.ldaca.org/ld.htm (7 Oct. 2001). "Learning Disabilities - Reading Initiatives." http://www.ldinstitute.org/readgrade3.htm/ (7 Oct. 2001). Rose, Mike. "Lives on the Boundary." The Presence of Others. ED> Andrea A. Lunsford. Boston: Bedford / St. Martin's, 2000. 105-118.

Saturday, January 11, 2020

Islam and Religious Group Essay

†¢Religious groups (based on http://religions. pewforum. org/pdf/affiliations-all-traditions. pdf) oChristianity †¢Evangelical Protestant †¢Mainline Protestant †¢Historically Black Churches †¢Roman Catholic †¢Latter-Day Saints (Mormons) †¢Jehovah’s Witnesses †¢Orthodox (Greek, Eastern) oJudaism (Orthodox, Conservative, or Reform) oBuddhism (Theravada or Mahayana) oIslam (Sunni, Shia, Sufism) oHinduism †¢Ethnic groups (based on divisions in U. S. Census Bureau documents) oAsian (Asian descent) oBlack (African descent). oHispanic and Latino (South or Central American descent) oPacific Islander (Polynesian descent) oWhite (European descent) Part III Answer the following questions in 150 to 250 words each about the religious group you selected: †¢How does your selected religious group differ from other religious groups (such as in their beliefs, worship practices, or values)? †¢What has been the experience of your selected religious group with others that do not share its beliefs or practices? †¢In what ways has the religious group you selected contributed to American culture? †¢Provide specific examples of prejudice or discrimination your selected religious group has experienced. †¢What were the sources of this prejudice or discrimination? †¢Does what you’ve learned about this religious group help you understand it? In what ways? Answer the following questions in 150 to 250 words each about the ethnic group you selected: †¢How does your selected ethnic group differ from other ethnic groups (such as differences in ancestry, language, or culture)? †¢What has been your selected ethnic group’s experience with other ethnic groups? †¢In what ways has the ethnic group you selected contributed to American culture? †¢Identify some specific examples of prejudice or discrimination that your selected ethnic group has experienced historically. †¢What were the sources of this prejudice or discrimination? †¢Does what you’ve learned about this ethnic group help you understand it? How? Part IV Answer the following questions in 150 to 250 words each: †¢How are the prejudice and discrimination experienced by your selected religious group and ethnic group similar? †¢How are they different? †¢Can you draw any conclusions about discrimination from this comparison.

Friday, January 3, 2020

Marriage in the 1800s Essay - 1802 Words

Jim Furdine February 7th 2014 ENC 1101 Ms. Dominique Marriage Portrayed by Women in the 1800s Marriage has been portrayed as many things throughout the years. In the short stories, The Story of an Hour by Kate Chopin and A Jury of Her Peers by Susan Glaspell both portray marriage, and how it does not always bring happiness. Each story was written by a married woman in the 1800s, this could reveal and interrupt how the lives of a married woman were in their time period. In each story, the main character is woman being overpowered by her husband, then when they find out they could be ‘free’ a sudden sigh of relief comes to mind. Only to be either be mislead or to feel trapped again. The authors Kate Chopin and Susan†¦show more content†¦To contrast, in The Story of an Hour, Kate Chopin’s main character sacrificed her freedom for marriage and was accepting the life she was to continue to live. In Glaspell’s, A Jury of Her Peers, the main character, Minnie sacrificed her freedom for marriage as well, but when she was unhappy she acted on her feelings and did something about it. She supposedly murdered her husband. Glaspell’s work relates to her life, because she was influenced by her life, the short story was based on an investigation she did while she was a reporter, this relates to her text, because it acted on her feelings and life events to make herself happy as did he career as a journalist. Each outcome in the story is different. Each character’s life was changed due different actions. Their unhappiness was not solved by freedom, since they did not get the freedom they desired. Lastly, each story had a woman character that scarified her life and freedom for marriage, and their unhappiness was solved. To compare, each protagonist was suffering from a life in which they did feel they were not their happiest. To compare, each story, the main characters were unhappy with their lives, and their unhappiness was solved due to death. In each story, death solved the problems that each protagonist had, in Chop in’s, The Story of an Hour, the main character was unhappy, when she found out her husband was dead, while grieving she realized she is now free to do withShow MoreRelatedMarriage And English Society Within The 1800 S1322 Words   |  6 PagesJane Austen provides her readers with insight into marriage and English society within the 1800’s. In Emma, the story establishes the idea that society could not function without marriage and how the institution of marriage defined one’s social status. Marriage, a broad theme in this book, can be broken down throughout. Emma’s sister has gone off after getting married and left her alone. After her sister’s marriage, Emma proclaimed that she was not destined for love and made herself the town’sRead MoreInterracial Issues Among Marriage, And Criminal Prosecution Between The 1800s And The 1900s934 Words   |  4 PagesDuring the terrible times of the 1800’s and 1900’s when the blacks and whites were racially separated terrifying events occurred to many people of color. The decimation was beyond the unnecessary, the killings and insults were highly common on the black community. Therefore a major problem during the time was the idea of marriage, in which the whites and blacks could only marry there race. In today’s statues that idea sound profound, but during the times of the correctional era it was not easy forRead MoreWomens Role in Marriage1327 Words   |  6 Pageshome, which included pro viding care for the children, doing chores, and making goods. During these times women were required to be subservient to their husbands and had little say in the matters outside of the home or outside her â€Å"place.† During the 1800s women were essentially the possession of their spouse, they were not allowed to keeps their earnings, inheritance, nor their freedom. Once married, often very young, the woman became one with her husband and followed his rules within and outside ofRead MoreBreaking Away From Society: A Doll’s House by Henrik Ibsen Essay1228 Words   |  5 Pagesaddress a more important issue of the time: marriage ideals. During this time, marriages were nothing but a masquerade. Husbands and wives hid behind their commitment, and were overly focused on the appearances and opinions of society. 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Sometimes it is beneficial for characters like Fanny, (Sarah Elizabeth Keyes), who marries John Dashwood, (Alex Givens), and acquires power. For others, it is an unnecessary circumstance forced upon them as in the case of Edward Ferrars, (Rishan Dhamija). Making sure you stay within your social class is very i mportant to people of this era, and in order to do thisRead MoreJane Austen’s Novel Pride and Prejudice Essay874 Words   |  4 PagesRecipe for Happiness â€Å"A large income is the best recipe for happiness I ever heard of† (Austen). The bluntness of this quote fully encompasses the main theme of an advantageous marriage for the English novelist, Jane Austen. Her realism, biting irony and social commentary have gained her historical importance among scholars and critics (Southam). Austen’s major novels, including Pride and Prejudice, were composed between the years 1795-1815. During those twenty years England was at the height ofRead MorePride And Prejudice By Jane Austen1693 Words   |  7 Pagesto marriages. This tale specifically focuses on one of the eldest daughters, Elizabeth Bennet, as she discovers the true meaning of love from an unexpected source. Despite the fact that this story is about love, it displays many characteristics that were typically of the time period the book is set in, especially in regards to marriage. The interaction between the characters of the novel displays and creates a theme of the im portance of social standing in the social institutions of the 1800s. TheRead MoreJane Austens Pride and Prejudice Essay1276 Words   |  6 Pagesin Victorian Era by pointing out the flaws with the recurring themes of marriage versus love and gender roles through dramatic irony and character relations. All relationships and the idea of true love tend to be obscured by this materialistic society that is based on wealth, power, title, and connections. Jane Austen constantly paints the Victorian scene of the socialite women gathering to discuss about the idea of marriage as Charlotte Lucas points out that â€Å"there is much gratitude or vanity in

Thursday, December 26, 2019

Drugs Misuse By Young People - 2081 Words

Drugs misuse by young people is apparent in our society today as much as it was in the past. The broadening problem of drugs being easily available is something that is becoming a serious issue and must be addressed. This essay aims to explore the factors why young people are abusing drugs, the kind of illicit narcotics that are becoming increasingly popular and the environmental causes of drug abuse. This essay understands the misuse of drugs to be the habitual taking of a mind-altering narcotic, used recreationally and which has the power to become addictive. Not only can it have a severe impact on the user’s brain, but it can have a profound affect on the person’s family life and their interaction with people due to the control it can have over the mind. There is a drug classification system in the UK which was included in the Drug Misuse Act 1971 which splits illegal drugs into three classes. Class A drugs, are those that are most harmful and have severe penalties in courts of law. These include drugs such as heroin, cocaine and ecstasy. If caught in possession of large amounts of these drugs, you can be imprisoned for up to seven years. Class B drugs, which are classed by the Act as less harmful but still lethal, are drugs such as amphetamines, cannabis and ketamine. The latter was once Class C drug, however in February of this year it was reclassified due to the findings of Advisory Council on the misuse of drugs, which showed evidence of the severe psychological andShow MoreRelatedThe Purpose Of This Paper Seeks To Analyze The Effects1208 Words   |  5 Pagespaper seeks to analyze the effects of prescription drug abuse. In the first article identified the author seeks to identify the differences between peer and parent influenc e on the misuse of prescription drug as it relates to ethnicity. 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A food addiction is obsessive-compulsive relationship people have with food. Eating food is both vital and important in our everyday lives to give our bodies the nutrients, vitamins and calories that it needs. â€Å"Compulsive overeating, also referred to as food addiction, is characterized by an obsessive-compulsive relationship to food† (Karim, 2012, p. 7, para. 2). When people overeat, they engage in episodes of uncontrolled eating and will often find themselves consumingRead MoreEffects Of Alcohol On The Consumption Of Alcohol1288 Words   |  6 Pagesor injury. There is, however, an issue with the misuse and abuse of alcohol in Australia across all age groups. This paper will discuss the use of alcohol in Australia broadly before focusing on the consumption of alcohol in the 16-29 year old age group. This essay will also discuss the impacts of alcohol consumption in the short term and the long term. 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The chapter aims to discover the prevalence of substance misuse, the character of individuals that misuse substances and the availability of substances on UK streets. The effects of this on individuals, families and community’s will be explored, as will the results this has on the UK prison population. We will end this chapter with a brief exploration of why individuals use substances, and why they becomeRead MoreSocial Evil15 17 Words   |  7 Pageslonger know or look out for one another, which left people feeling isolated, lonely and fearful – particularly the elderly and those who live alone. People also spoke of a decline of community in a more abstract sense, in terms of a lack of public spiritedness or social responsibility. Older people spoke about how different things used to be: While it was recognised that new kinds of communities were emerging (such as virtual or online communities) people felt these were an inadequate substitute for theRead MoreEffects Of Marijuana Abuse On The Health Of Teens Aged 13-19 Essay1684 Words   |  7 PagesPlant (2016) 36% of teenagers in the UK have taken illegal drugs at some point of their life. According to European School of Survey Project on Alcohol and Other Drugs abuse (2016) teenagers in Britain are more likely to misuse drugs as compared to youngsters in Europe. This survey also found that 40% teenagers in UK has tried substance. Cannabis is found to be most common drug used by teens (Patton et al., 2002). Cannabis is a class B drug and is illegal in UK. Source of Cannabis is a flowering plantRead MoreAdhd : An Attention Deficit Hyperactivity Disorder761 Words   |  4 Pages ADHD Stimulant Drugs What is ADHD? ADHD is an Attention-Deficit Hyperactivity Disorder. Any child can be sometimes inattentive, hyperactive or impulsive (www.library.iated.org). However, children with ADHD repeat these symptoms every day that have an impact at home and school. Children’s behaviors seem inappropriate for their age. These symptoms are present for at least six months at home, school, or with friends and affect a social or academic functioning. Also, these symptoms appear beforeRead MorePrescription Drug Abuse1483 Words   |  6 Pageswill be addressing is parents, caregivers and school educators about the dangers of prescription drugs and how we can better educate teenagers and young adults on the dangers of abusing them. There are many ways that we can teach and educate our teenagers and young adults, but it’s important that families, schools and communities are involved. The rate of prescription drug overdose among teenagers and young adults have sky rocketed over th e past several years. This has become a growing epidemic and if

Wednesday, December 18, 2019

Concert Report Essay - 454 Words

On June seventh at eight o’clock pm I attended a concert at Beneroya Hall. The concert was part of the Masterpiece series, performed by the Seattle Symphony and conducted by Hermann Michael; also including a special performance by the pianist Hà ©là ¨ne Grimaud. The performance included four pieces, two by Ludwig Van Beethoven, one by Maurice Ravel, and the last was by Richard Strauss. The two pieces by Beethoven were; Overture to The Construction of The House, and piano Concerto No. 4 in g major, Op. 58. The piece by Ravel was Pavane for a Dead Princess. Finally the last by Strauss was Death and Transfiguration. I truly enjoy going to the symphony, the music is quite a bit better than on any type of recording I have ever heard. The segment†¦show more content†¦She was so into the music, swaying around almost dancing over the keys. I’m not even sure if her eyes were open half the time. She just made the show. I also found out that I still have a lot to learn about music, because well after intermission it was enounced that there would be no break between the last two pieces. The last two pieces sounded a lot alike and I never noticed a real break between the two so I’m not sure when the Death and Transfiguration started and when Pavane for a Dead Princess ended. There must be a lot of differences between the two I just never could distinguish what they were. I will have to spend the rest of my life learning about music that no one else I know likes, and just go to concerts alone, and occasionally tune my radio to KING Fm. But that’s ok I will look forward to the challenge. During Intermission I’ll just have to strike up conversations about the pieces that were played in the lobby and in the line of the ladies restroom. (I think I figured it out, what you ask did I figure out, well the piece Overture to The Construction of The House Op. 124, what I’m referring to. I’m pretty sure that it was written about the time that the House of Lords in London was being rebuilt. Something about a devastating fire and then a huge design and construction competition over the new rebuild of The House. I even saw one of the designs on the Antique Road Show; it was a huge highly detailed painting that would completely cover aShow MoreRelatedConcert Report : Concert 753 Words   |  4 PagesMusic 21 Concert Report I went to a chamber music concert called Attravereso il Mare, on October 17 at 8 pm at Boston Court located in Pasadena. This project performs Italian-American songs which represent the Italian-American culture. My friend and I arrived 1 hour early, and people kept coming. Most of them are family and friends, and only few of them were coming alone, but they all had more concert experience than me because this was my first time attending any kind of concert. This concert was inRead MoreConcert Report On Music Concert1143 Words   |  5 PagesName Music32 Concert Report Professor Name 2015.6.2 Music Concert Report On Sunday, May10 2015, a concert was held in The Broad Stage. The concert was played by Santa Monica College Symphony Orchestra, whose conductor is Dr. James Martin. For this concert, I would identify myself as a referential listener at this concert. I say this becauseRead MoreConcert Report1222 Words   |  5 PagesSleeping Beauty Lauren Lehman On April 21, 2014 I watched the online performance of Sleeping Beauty performed by the Jacobs School of Music at the Musical Arts Center in Indianapolis. I have never personally been to the Musical Arts Center, but from the online streamed video, the place looks magnificently huge and phenomenal. The stage was absolutely stunning. It was big, vibrant, and breathtaking. It made it look as if you actually went back in time and were a part of the performance. TheRead MoreConcert Report690 Words   |  3 PagesThe concert that I attended was the Euclid quartet at the first Presbyterian Church. The church itself wasn’t very big but there was a lot of people there and it made it really hard to find a parking space. On the inside the church looked like any ordinary chapel. The large amount of people that were there were dressed very nice and once again I was under dressed. I did however notice more students at this one than I did at BVSO and they were also underdressed which made me feel better. The performersRead MoreConcert Report : Concert At Duke University Essay1128 Words   |  5 PagesConcert Report The concert that I attended took place inside Nelson Music Room at Duke University. The room was on the smaller side but had balconies for people to sit so they could watch the performance from up high. The floors were carpeted and they had theater seats that folded back when the seats were done being used. 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Hostel Pangea is a small coffee and bar place located in Tijuana. It hosts events and workshops for all ages. It was not what I expected, since it was my first time in a punk/rock concert. I actually thought I would feel very uncomfortable and out of place, but not, it was a very friendly place, and all the people there were very nice and outgoing. It was a great experienceRead More Concert Report Essay1073 Words   |  5 Pagesthis concert report I chose to go to a performance of student composers held at the Kimball Recital Hall. I chose this one because I wanted to see some of the talent that my peers have in the music realm, and also it was one of the only concerts I have been able to attend because I usually work at night. It was impressive to hear pieces composed by students. I cannot imagine creating something as complex as a musical composition, much less actually performing it, so this aspect of the concert wasRead MoreConcert Report Essay594 Words   |  3 PagesSpreckles Organ Society’s Organ Concert Dr. Carol Williams’s organ plays were just fantastic. Despite the fact that seeing the instrument called, â€Å"organ† was my first time, it was pretty impressive how that instrument worked. All the pedals and the three layers of keyboards were just as complicated as a calculus math problem. The concert was played at the Spreckels Organ Pavilion at Balboa Park. The surrounding was not too bad. Although the concert day was Sunday, it was quite crowded. BesidesRead Moreconcert report Essay1388 Words   |  6 Pagesï » ¿McKenzie Maxwell Professor McDaniels MUSI 1306-303 22 October 2014 Concert Report One: Marion Anderson String Quartet Concert I chose the genre string quartet and attended a concert at First Presbyterian church on October 19th, 2014. Because of its location the sanctuary where the concert took place had many stained glass windows. It was marvelous and in my opinion well suited the feel of classical music. The audience was very responsive and attentive. They applauded when the musicians appeared

Tuesday, December 10, 2019

Forensic Toxicology and Dermal Sensitization †MyAssignmenthelp.com

Question: Discuss about the Forensic Toxicology and Dermal Sensitization. Answer: As a toxicologist assigned to determine whether a novel chemical has the capability of dermal sensitization production, I will use the following steps to explain how I would test for dermal sensitization. In undertaking this task, I will also present an explanation for the model/test system I would further provide a brief description of how the test is run and how the results are interpreted. To undertake this assignment, I have chosen the Guinea Pig Maximization Model because it is easy to use and has been previously effective in testing the production of dermal sensitization. GPMT Overview At least ten animals are utilized in treatment cohort and a minimum of 5 animals are used in control cohort/twenty-test and ten-control animals. Induction is then undertaken originally on skin of shoulder area with 3 intradermal injections on day zero. Control animals also receive 3 intradermal injections, however, only vehicle is utilized in place of test substance. Five to seven days later animal skin is smeared with 0.50 mL of ten percent sodium-lauryl-sulfate in Vaseline. This painting is done to create a local irritation, twenty-four hours later, test substance is applied for 48 hours under occlusion (Varns et al., 2016)). Challenge is then undertaken on twentieth-twenty-second day with reapplication of patches for twenty-four hours and assessment of results done at 48 hours and 72 hours following challenge. Magnusson and Kligman grading scale is then utilized for evaluation. Zero equal no observable change, one equals discrete/patchy erythema, two equals moderate and confluent erythema while three indicates intense erythema and swelling. Aim: To establish the sensitizing prospective of a test article when it is dermally applied. The test conforms to the established OECD Guideline 406 and EPA-OCSPP 870.2600 standards. Principle: The contact dermal sensitization remains an immunological procedure whereby a host animal, via recurrent skin-exposure, needs a particular allergic-sensitivity to a substance. Guinea Pig Maximization (GPMT) model will have the contact dermal sensitivity being demonstrated as a surged erythema. Test Overview: The following sections generally details briefly how the Guinea Pig Maximization Model is used to undertake and interpret the dermal sensitization test and results respectively. Typical Testing Time: Approximately ten wees encompassing pre-test, central test and reporting times. Induction Stage: In the 1st induction stage, it will encompass a manifold intradermal injections to test using twenty animals. I will use an adjuvant (fifty percent Freunds Complete Adjuvant; FCA), the test article (TA) alongside the mixture of TA and FCA. I will administer the mixture to the dorsum (clipped free of hair) in duplicate 0.10-ml injections (Sato, Yuta Kusaka, 2017). I will select TA concentration that does not yield local ulceration/necrosis. The TA concentration I choose will also be free from systemic toxicity. I will then treat Ten Vehicle Group animals identically with an exemption of replacing vehicle for the TA. I will then examine the treated sites of every animal and score them at twenty-four-and forty-eight hours following the injections (Hamada, Bruze, Zimerson, Isaksson Engfeldt, 2017). After 7 days, I will apply the 2nd induction which is applied administered topically via the application of a TA-saturated two-centimeter by four-centimeter section of the Whatman No. one filter paper over the past already injected intradermal sites clipped free of hair for forty-eight hours as an obstructed exposure. I will tolerate TA concentration in the similar manner, however, this time using the vehicle. I will then examine the treated sites of every animal and score them at forty-eight hours following patch application. Challenge Phase: After the fourteenth day following the topical induction, I will topically challenge the animals in both Vehicle Group and TA Group over a twenty-four, occluded exposure. I will do this by applying a two-centimeter by 2-centimeter section of Whatman number one filter paper saturated with the uppermost non-irritating TA concentration on left flank. I will apply vehicle in similar manner as TA. And I will also apply patch to right flank of every animal. I will then examine and score the challenge sites after twenty-four hours and forty-eight hours following the removal of patch (Lewandowski Cohen, 2016). Interpretation: I will regard a score of one/greater than 1 for redness in the GPMT a positive response. I will determine sensitization prospective on the basis of proportion of the animals showcasing a positive reaction. A 6-animal screening study is appropriate in determination of the suitable induction (topical and intradermal) and challenge (topical) concentrations. References Hamada, H., Bruze, M., Zimerson, E., Isaksson, M., Engfeldt, M. (2017). Factors Affecting the Concentration of Diphenylmethane-4, 4-Diisocyanate in Freunds Complete Adjuvant. Can They Affect the Outcome of the Guinea-Pig Maximization Test?. Journal of Clinical Experimental Dermatology Research, 8(4). Lewandowski, T. A., Cohen, J. M. (2016). Skin sensitization risk assessment: Considering available data for weight of evidence assessments. Regulatory toxicology and pharmacology: RTP, 82, 186-187. Sato, K., Yuta, K., Kusaka, Y. (2017). Skin Sensitization Model Based on Only Animal Data by Qualitative Structure-Toxicity Relationships (QSTR) Approach. In Allergy and Immunotoxicology in Occupational Health (pp. 93-101). Springer Singapore. Varns, K., Finnema, S. J., Stepanov, V., Takano, A., Tth, M., Svedberg, M., ... Halldin, C. (2016). Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand,[18F] Lu AF10628. International Journal of Neuropsychopharmacology, 19(8).